Vitamin D as a marker of cardiovascular risk?


OBJECTIVES: Vitamin D is known especially for its important function in maintaining the calcium and phosphorus homeostasis, but besides this traditional role, the studies prove its extra-skeletal impact, too. The pleiotropic effect of vitamin D is shown for example in affecting the terminal cell differentiation, the antiproliferative effect, participation in the regulation of immune system, affecting the insulin secretion and sensitivity, vitamin D deficiency has been proven also in many diseases like diabetes mellitus, cancer, autoimmune diseases, heart failure, and many others.

METHODOLOGY: Based on the processing of the latest data from the scientific literature, the authors reassessed the pattern of current knowledge and expanded it in the field of study.

RESULTS: The association of hypovitaminosis D with the increase of cardiovascular risk is indicated by the observational studies, yet the effect of vitamin D supplementation on reduction of cardiovascular risk has not been reliably proven.

CONCLUSION: It emerges that this area of research needs realization of further properly designed prospective studies, which results could be further implemented in the clinical practice for the patient´s benefit (Tab. 1, Fig. 1, Ref. 51). Text in PDF

KEY WORDS: vitamin D, cardiovascular risk, autonomic dysfunction.

Lek obz 2022, 71 (8): 278-283

Katarína VLČKOVÁ 1, Martin WAWRUCH 2, Denisa ČELOVSKÁ 1

1 I. interná klinika Lekárskej fakulty Univerzity Komenského a Univerzitnej nemocnice Bratislava, Univerzita Komenského v Bratislave, prednostka doc. MUDr. S. Kiňová, PhD.
2 Ústav farmakológie a klinickej farmakológie Lekárskej fakulty Univerzity Komenského, Univerzita Komenského v Bratislave, prednosta prof. MUDr. M. Wawruch, PhD.


VLČKOVÁ K., WAWRUCH M., ELOVSKÁ D.: Vitamin D as a marker of cardiovascular risk? Lek obz 2022, 71 (8): 278-283