Lekársky obzor 2/2021

Lekársky obzor 2/2021

Lek Obz 2/2021Klinická štúdia
Elvin A. MELIKOV, Alexey Y. DROBYSHEV, Sergey V. SHAMRIN, Andrey A. MITEREV:  Použitie distrakčnej osteogenézy na vaskularizované autografty u pacientov s defektami kĺbov a deformitami rôznej etiológie       

 
Experimentálna práca
Viktor  Konoplitskiy, Ruslan Shavliuk, Dmytro Dmytriiev, Kostiantyn  Dmytriiev, Serhii Maistruk, Oleksandr  Dobrovanov, Marián Vidiščák: Modelovanie a matematické odôvodnenie chirurgického prístupu v mini-invazívnej chirurgickej liečbe pylonidálnej choroby u detí        

Clinical study
Elvin A. MELIKOV, Alexey Y. DROBYSHEV, Sergey V. SHAMRIN, Andrey A. MITEREV: The application of distraction osteogenesis on vascularized autografts in patients with jaw defects and deformities of various etiologies        

Experimental study
Viktor  Konoplitskiy, Ruslan Shavliuk, Dmytro Dmytriiev, Kostiantyn  Dmytriiev, Serhii Maistruk, Oleksandr  Dobrovanov, Marián Vidiščák: Model substantiation of surgical access in mini-invasive surgical treatment of pilonidal disease in children  

SUMMARY
Objective: Studying the effectiveness of rehabilitating patients with jaw defects and deformities of various etiologies using distraction osteogenesis after autologous transplantation of a vascularized autograft.
Methods: Analysis of the treatment of 60 patients with this pathology. The patients were divided into two groups: the primary group (n = 30), where distraction osteogenesis was performed after autologous transplantation of a vascularized autograft, and the control group (n = 30), where treatment included only distraction osteogenesis. The efficacy of the regimens was evaluated according to patient quality of life (EORTC QLQC-30 questionnaire) and histological and morphological data taken four months after treatment.

SUMMARY
Background: Dissatisfaction with the results of treatment of pilonidal disease in children leads to the search for new ways to improve the methodology of its surgical treatment.
Objective: To create a model for the spatial justification of the form and parameters of surgical access in the treatment of pilonidal disease in children in all forms of it.

SÚHRN
Úvod: Syndróm karpálneho tunela je najčastejším úžinovým syndrómom a zároveň aj najčastejšie diagnostikovaným, liečeným a hláseným profesionálnym ochorením na Slovensku. Pri jeho vzniku sa okrem profesionálnych faktorov môžu uplatňovať viaceré rizikové faktory a ochorenia všeobecného charakteru, ako napríklad zmenené anatomické pomery po úraze v oblasti zápästia, ženské pohlavie či obezita. Na podiel diabetes mellitus, tyreopatií a reumatoidnej artritídy v patogenéze sú v literatúre nejednotné názory.

SUMMARY
Introduction: Treatment of patients with primary osteoarthritis (OA) remains an urgent problem, despite the fact that there are many different conservative and operative approaches to the treatment of this pathology.
The aim of the study was to investigate the parameters of joint pain and their relationship with indicators of excretory function of the pancreas in patients with primary OA with comorbid conditions.
Materials and methods: 132 outpatients with primary OA in combination with diseases associated with decreased excretory function of the pancreas were examined. The diagnosis of OA was established on the basis of diagnostic criteria of the ACR and the European League Against Rheumatism (EULAR). To assess the depth of the decrease in the secretory function of the pancreas, the level of fecal α-elastase was determined.
Research results: There was a decrease in excretory function of the pancreas in patients with primary OA in the content of fecal α-elastase and coprogram score, which were statistically different for the control group (p<0,05). In patients with OA with comorbid conditions with excretory insufficiency, a statistically significant increase in the indices of VAS, Leken, WOMAC, a decrease in the Harris index relative to those in the control group (p <0.05).
Discussion: According to the rank indices of pain and the attitude of the McGill questionnaire, despite the chronic nature of pain, patients with primary OA in combination with a decrease in excretory function of the pancreas paid much attention to sensory characteristics that are characteristic of emotionally stable individuals. The inverse correlations between the Leken index and the fecal α-elastase content, the Leken index and the coprogram score, as well as the high strength of the direct correlations between the Harris index and the fecal α-elastase content were also found.
Conclusions: The identified correlations proved the interdependence of the strength of the joint pain syndrome in primary OA and a decrease in the excretory function of the pancreas.
Key words: primary osteoarthritis, excretory insufficiency of the pancreas, clinical indices of joint pain, fecal α-elastase.
Lek Obz, 2021, 70 (2): 62-64



Liliya S. BABINETS, Iryna M. HALABITSKA

The department of primary health care and general practice - family medicine, I. Horbachevsky Ternopil National Medical University, Ukraine, head  prof. MD. L.S. Babinets, DSc.


CITE:

BABINETS L.S., HALABITSKA  I.M.:   Characteristics of joint pain in patients with primary osteoarthritis and comorbid conditions with exocrine pancreatic insufficiency.  Lek Obz, 2021, 70 (2): 62-64

SÚHRN
Východisko: Hodnotenie zdravotného uvedomenia a správania obyvateľstva vo vzťahu k stravovacím návykom patrí medzi jeden z významných indikátorov kvality života.
Súbor a metódy: Výskumný súbor tvorilo spolu 11 196 respondentov. V roku 2013 tvorilo súbor 3 679 respondentov (32,9 %). Z toho 1 840 mužov (50 %) a 1 839 žien (50 %). V roku 2016 bolo respondentov 3 773 (33,7 %), mužov bolo 1 872 (49,6 %) a žien 1 901 (50,4 %).  3 744 respondentov (33,4 %) bolo v roku 2019, pričom mužov bolo 1 866 (49,8 %) a 1 878 žien (50,2 %).

SÚHRN
Približne tretina hospitalizovaných pacientov je poškodzovaná nežiaducimi liekovými reakciami vrátane poliekovej horúčky, ktorá tvorí cca 3 – 5 % prípadov nežiaducich účinkov liekov. Diagnóza sa stanovuje „per exclusionem“, rizikové faktory doteraz neboli jasne definované. Presná incidencia však nie je známa kvôli obtiažnej diagnostike a nedostatočnému hláseniu prípadov. Medzi ohrozené skupiny patrí hlavne staršia populácia zaťažená polypragmáziou a pacienti s imunodeficientným stavom. Tento prehľadový článok sa zameriava na mechanizmus vzniku poliekovej horúčky, popisuje odlišnosti v klinickom obraze a diagnostike, uvádza prehľad najčastejších liekov  zodpovedných za túto komplikáciu liečby.

SUMMARY
Background: Occurence of extraskeletal myxoid chondrosarcoma (EMC) in the genitourinary tract is extremly rare. This case report presents diagnostics, treatment and follow-up of a patient with an extremly large EMC of the scrotum.
Case report: A 58-year-old male without relevant comorbidities presented with a non tender huge scrotal mass. The mass was first noted about 15 years prior to consultation, with rapid growth in the last 6 months. The major complaint of the patient was his restricted mobility due to the scrotal mass (size 23x17x14 cm, weight 3500 g). Imaging investigations showed a solid mass in the paratesticular space, normal testicles and multiple pulmonary metastases. The patient underwent bilateral orchidectomy through inguinal incisions followed by removal of the entire scrotum. Operation wound healed without complications. As there is limited experience with any other treatment options except surgery, we were reluctant to use them. Despite progression of pulmonary metastases, the patient’s quality of life increased and remained stable during first 12 months after surgery. Subsequently, he suffered from several attacks of bronchopneumonia and died 36 months after surgery.

SUMMARY
Introduction: Carpal tunnel syndrome is the most common entrapment syndrome and most commonly diagnosed, treated and reported occupational disease in Slovakia. Except from the occupational factors there are several risk factors and general diseases known in its etiology, such as altered anatomical conditions due to wrist injury, female sex, obesity. In literature, there are different views on portion of diabetes mellitus, thyreopathy and rheumatoid arthritis in the pathogenesis.

SUMMARY
Introduction: The assessment of the health awareness and behaviour of the population in relation to eating habits is one of the important indicators of quality of life.
Methods: The research group consisted of a total of 11,196 respondents. In 2013, the group consisted of 3,679 respondents (32.9%) of which 1,840 were men (50%) and 1,839 were women (50%). In 2016, there were 3,773 respondents (33.7%), 1,872 men (49.6%) and 1,901 women (50.4%). In 2019, there were 3,744 respondents (33.4%) with 1,866 (49.8%) men and 1,878 women (50.2%).

SUMMARY
Approximately one third of hospitalized patients are harmed by adverse drug reactions, including drug fever, which accounts for approximately 3 - 5 % of adverse drug reactions. The diagnosis is made „by exclusion“, risk factors have not yet been clearly defined. However, the exact incidence is not known due to the difficulty of diagnosis and insufficient case reporting. Vulnerable groups mainly include the elderly population burdened with polypragmacy and patients with an immunodeficient condition. This review article focuses on the mechanism of drug fever, describes the differences in the clinical picture and diagnosis, provides an overview of the most common drugs responsible for this complication of treatment.