Zuzana FEČKOVÁ, Katarína FEDOROVÁ, Natália ŠTECOVÁ

Quality of Life in Patients with Multiple Myeloma

Multiple myeloma is a rare oncohaematological disease characterized by a number of clinical symptoms and genomic changes. Lifelong treatment is challenging and significantly affects the physical, emotional and social life of the patient and his family. Part of the treatment plan is specific treatment and supportive therapy. In the past decade, advances in the treatment of myeloma have led to the significant improvements in overall patient survival and quality of life.
Key words: multiple myeloma, symptoms of disease, quality of life.

Lek Obz (Med Horizon), 2019, 68(9): 271-274

Branislav JAĎUĎ, Martin SMATANA, Ľubica HLINKOVÁ, Jana IVANOVÁ, Róbert RUSNÁK, Róbert BABEĽA

Lost productivity costs associated with premature death in working age patients due to multiple myeloma in Slovakia: Results from national study in 2018

Haematological malignancies are a collection of 140 different diseases that require urgent medical attention once a patient has received a diagnosis. The outcomes for patients with multiple myeloma (MM) have dramatically changed in the past decade with introduction of new and more effective innovations. Improved survival was noticed compared to a nearly stagnant survival during the preceding three decades which leads to accumulating the economic burden due to rising costs and increased demand for innovations. According to the Slovak national literature, there is currently no study, that calculates losses in labour productivity due to death or premature death in working age patients with multiple myeloma. Key purpose of our research was to provide detailed information related to one of the economic aspects of blood cancer - to estimate loss of labour productivity caused by the premature deaths of working age multiple myeloma patients in Slovakia.
Key words: lost produktivity, multiple myeloma, costs, economic aspects.
Lek Obz (Med Horizon), 2019, 68(9): 275-279


Multiple myeloma costs in Slovak Republic: analysis of the total costs for model patient in productive age

Implementation of innovations in healthcare is essential part of improving quality of provided healthcare, however on the other hand, it influences the expenditures radically. From the pharmacoeconomical point of view, precise and exact identifying and quantifying the costs on healthcare is, as with the diagnosis of multiple myeloma, so with other diseases, crucial. Besides the direct costs, including diagnostics costs, drug therapy costs, hospitalization, etc., it is necessary to take into account also indirect costs concerning sickenss benefit, disability pension, costs associated with productivity loss due to premature dead etc. As soon as the accurate evaluation of these parameters is done, these data can be used when improving the quallity of estimation of either current or innovative technologies in therapy of multiple myeloma.   
Key words: multiple myeloma, direct costs, indirect costs, sickenss benefit, disability pension.
Lek Obz (Med Horizon), 2019, 68(9): 280-285

Katarína FEDOROVÁ, Zuzana BALÁŽOVÁ, Branislav JAĎUĎ, Jana IVANOVÁ, Róbert MAMRILLA, Róbert RUSNÁK

Social security area of patients with multiple myeloma in connection with indirect costs in Slovakia

Indirect costs associated with cancer can be considered significant on the basis of data from relevant foreign sources. Nevertheless, the analysis of indirect costs is not part of the health technology assessment process in the Slovak republic. Authors describe the functioning of the social security system in relation to patients suffering from multiple myeloma. They examine what specific assistance in the form of benefits and allowances are these patients entitled to. They are looking for an answer to the question of how much money we spend on a model myeloma patient within the social security system. The authors' conclusions should serve as a basis for a public debate on the true value of innovation.
Key words: multiple myeloma, indirect costs, social security, social insurance, innovative treatment.
Lek Obz (Med Horizon), 2019, 68(9): 286-290


Social determinants of health in School Aged Children - Key Results of International Survey

Objective. The goal of the work was to get the data about 11, 13 and 15 years old students (schoolchildren), which are representative for the population in Slovakia with health related behavior of students in their social context and better understanding of the mechanisms that affect the differences and changes in health of students (schoolchildren) and their risk behavior.
Material and Methods. They have been 14 816 students (schoolchildren) registered in classes, in selected schools who participated in the study. Finally, the questionnaire was completed by 8 902 of students (schoolchildren), which is the 60 % of the rate of return.
During a phone conversation with the schools, which agreed to participate (109), randomly  were selected the classes, where have been the data collection. The data were processed in the SPPS Windows program.
Key words: social determinant of health, school population.
Lek Obz (Med Horizon), 2019, 68(9): 291-296


Detection of hepatitis C in pediatric patients

Backround: The aim of our work was to detect the presence of hepatitis C virus in children 0-12 months of age in HCV RNA positive mothers. In this work we focused on monitoring the presence of HCV RNA positivity in children  of mothers who had previously found HCV RNA positivity. We monitored the possible transmission of virus from mother to child.
Patients: Serum samples of pediatric patients aged 0-12 months with suspect viral hepatitis C acquired after birth from HCV RNA positive mothers were from the territory of the Slovak Republic.
Methods: We used an RT-PCR method based on automatic extraction, purification and amplification of nucleic acids to detect and quantify the hepatitis C virus (HCV) in the serum of pediatric patients.
Results: Hepatitis C virus was not detected in all tested serum samples from pediatric patients across the Slovak Republic.
Conclusion: In the laboratory, over the past four years, we have tested samples of serum from children's patients for the presence of hepatitis C. We did not detect the presence of hepatitis C virus, which is related to the likely HCV RNA negativity of mothers during pregnancy.
Key words:  HCV positivity of mothers, pediatric patients, pregnancy, RT-PCR.
Lek Obz (Med Horizon), 2019, 68(9): 297-299


Quality Standards Diagnostic and Therapeutic Methods in Paliative Care apply to each of us

European standards and norms of paliative care became the foundation of diagnostic and terapeutic proceses' development in the Slovak Republic. As of 1 January 2019 thirty-one standards of diagnostic and therapeutic proceses from different medical fields became applicable. This presents the long term process of health care quality development and it is expected that further development of standards will substantially contribute to the improvement care management. Standardised proceses should eliminate the usage of outdated methods in the diagnostic and therapy and provide the lead in the decision making and contribute to the legal certainty in the field of health care provision. The standards should bring exact instructions for health care personel how to proceed in diagnostic and therapy. This should ensure the equal access to the health care for all pacients in the Slovak Republic. The Standard No. 003 - Complex nursing management of patientin paliative care (adult) is applicable for the field of paliative medicine. This standard should be observed also by the social service facilities which provide the paliative care, however under different conditions concerning the financing the nursery performances. In this paper we also provide the overview on monitoring health of population within the EU. Monitoring report gave incentive for the preparation of the national standards of diagnostic and therapeutic procedures.
Key words: diagnostic standards, therapeutic standards, paliative medicine, paliative care, social work, social help, legislation
Lek Obz (Med Horizon), 2019, 68(9): 300-303


Working with scientific and profesional information as a necessary part of higher education. International science schools - complementary activity of education of medical students and young scientists

The profession of medical and healthcare workers requires lifelong learning, which is also regulated by law. Lifelong learning is often seen as a one-way process, a constant need for education, keeping pace with the latest scientific knoweledge. However, this process also has the second dimension, which is the transfer of experience and knowledge, the systematic search  for answers to a number of open questions in patients care, in other words, participation in research. Presenting and publishing clinical experience is an essential source of medical knowledge and a specialized database of medicine as a scientific discipline. We consider it necessary to add these capabilities to the curriculum of medical faculties.
Key words: lifelong learning, scientific education, medicine, curriculum.
Lek Obz (Med Horizon), 2019, 68(9): 304-306