Here are all the summaries from the Lekarsky obzor journal for citations. Full journal will be available in a few months.
Dávid KOVÁČ, Lucia PETRÍKOVÁ, Iveta ŠIMKOVÁ, Beata MLADOSIEVIČOVÁ: Pulmonary arterial hypertension: An Unexpected Complication of Anticancer Targeted Therapy
Pulmonary arterial hypertension (PAH) is a rare, rapidly progressive, potentially fatal disease. The classical pathophysiology oriented mainly on pressure, flow, shear stress, right ventricle wall stress has been enriched with better understanding of molecular changes and interactions of complex multicellular systems. Targeted agents offer more precise anticancer treatment options than standard chemotherapeutics, however, they are not free of new unexpected cardiopulmonary and other complications. Several new anticancer drugs, particularly tyrosine kinase inhibitor dasatinib, proteasome inhibitors bortezomib and carfilzomib and some other targeted drugs such as trastuzumab emtansine, rituximab, bevacizumab have been recognized as potential risk factors for PAH. There are no large series documenting a prevalence of PAH complicating these agents; some targeted drugs have been implicated only in case reports.
This article intends to summarise recent pathophysiological concepts of PAH associated with targeted therapy.
Key words: pulmonary arterial hypertension, targeted therapy, oncological patients, dasatinib, bortezomib, carfilzomib.
Lek Obzor (Med Horizon), 2019, 68 (3): 84 – 90
Zuzana LIŠKOVÁ, Katarína SLÁVIKOVÁ, Michal LIŠKA, Viera LEHOTSKÁ: Informations adeguacy of radiology request forms
Radiologic request forms are the basic form of communication between the clinician, radiologist, patient and the insurance company. Despite its legal and clinical relevance the availability of information on the request forms is insufficient.
We have examined 100 received subsequent radiologic request forms for musculoskeletal MRI and analyzed them for appropriate information. We examined if it contained information required by the expert guidelines of the Ministry of Health of the Slovak Republic concerning the ordering, executing, and control of laboratory and imaging exams and also by the methodological guidelines of the Healthcare Surveillance Authority. We also examined the information concerning the reasons for examination and the complexity of clinical data.
From the received request forms only 5 % was evaluated as excellent and containing all the necessary data. The most filled in information was the name of the patient (100 %), the least filled in information were a short medical history (8 %) and the results of previous exams (5 %).
The aim of this study was to objectify the level of availability of clinical information on the request forms for radiological imaging with its legal aspects. We uncovered deficiencies in the current system in relation to Slovak healthcare, but also in relation to international expert guidelines.
Key words: information, radiologic examinations, guidelines, request form.
Lek Obzor (Med Horizon), 2019, 69 (3): 91 – 94
Jana MALOVÁ, Daniel BÖHMER, Andrea PASTORÁKOVÁ, Mária OSTROŽLÍKOVÁ, Tatiana BRAXATORISOVÁ: Neural tube defects in chromosomally normal and abnormal human embryos and fetuses
The prevalence of neural tube defects worldwide represents 1-2 per 1000 neonates. In the isolated form they have multifactorial causes, and the empirical risk of recurrence in Central Europe is 2 %. As associated malformations they tend to occur sporadically, and in monogenic syndromes they follow Mendelian inheritance patterns with a high risk of recurrence or chromosomal syndromes. This paper is oriented on the evaluation of neural tube defects using a sample set of 94 embryos and fetuses with the focal abnormalities collected from the spontaneous and induced abortions and stillborn fetuses. The occurrence of various types of neural tube defects and their frequency was evaluated along with their abundance as the isolated neural tube defects or as neural tube defects associated with the developmental anomalies. The analysis of their karyotype performed helped us to differentiate the conditional multifactorial tube defects and the chromosomal or monogenic syndromes.
Key words: neural tube defects, spina bifida, anencephaly, encephalocele, chromosomal aberrations, multifactorial inheritance.
Lek Obzor (Med Horizon), 2019, 68(3): 95 - 100
Miroslava RABAJDOVÁ, Peter URBAN, Zuzana BISČÁKOVÁ, Peter URDZÍK, Mária MAREKOVÁ: Endometrial receptivity – A new challenge in diagnostics of infertility in the in vitro fertilization process
Determination of endometrial receptivity and selection of the right embryo for implantation is still one of the most limiting steps in the in vitro fertilization process. Time-lapse monitoring and preimplantation genetic diagnostic did not produce the expected results. It is a reason, why the successful implantation of the embryo does not reach even more than 30% from all implantation processes. We did not recognized till today a non-invasive marker, with high sensitivity and specificity, able to evaluate the readiness of the uterine endometrium for implantation and developmental capability of the human embryo. The study of new biomarkers (e.g., from embryo culture medium) could be a prospective indicator of embryonic developmental potential. Determining a biomarkers that would allow high-precision embryo selection in an in vitro fertilization program, would be significantly increase the success rate of assisted reproductive techniques.
Key words: infertility, non-perceptive endometrium.
Lek Obzor (Med Horizon), 2019, 68 (3): 101 – 104
Michal BERNADIČ, Jr., Marián BERNADIČ, Sr.: Nobel Prize in Physiology and Medicine 2018 – New hope for oncological patients
The Nobel Prize in Physiology or Medicine was awarded previous for cancer treatment, including surgery, radiation, and other strategies. Last year were awarded professors James P. Allison a Tasuku Honjo „for their discovery of cancer therapy by inhibition of negative immune regulation.“ They uncovered fundamental mechanisms regulating immunity and also showed how the immune system can recognize cancer cells. This described balance between accelerators and brakes is essential for tight control. They start the new strategy into a therapy for oncological patients. In 2010 an important clinical study showed striking effects in patients with advanced melanoma. Such remarkable results had never been seen before in this patient group.
Key words: Nobel prize, physiology, medicine, immune system, inhibition, cancer therapy.
Lek Obzor (Med Horizon), 2019, 68 (3): 105 – 107